P50 Implicates Adverse Clinical Outcomes in Pediatric Acute Respiratory Distress Syndrome by Reflecting Extrapulmonary Organ Dysfunction
Thompson, BT, Chambers, RC & Liu, KD Acute respiratory distress syndrome. N.Engl. J.Med. 377562-572 (2017).
Cheifetz, IM Pediatric ARDS. Breathe. Care 62718–731 (2017).
Hough, RF Recent advances in pediatric acute respiratory distress syndrome (PARDS). Running. Pediatrician representative 5228-236 (2017).
Wong, JJ-M. et al. Mortality in pediatric acute respiratory distress syndrome: a systematic review and meta-analysis. J. Intensive Care Med. 34563–571 (2019).
Beltramo F, Khemani RG. Definition and global epidemiology of pediatric acute respiratory distress syndrome. In Annals of Translational Medicine 7 (2019).
Suchyta, MR, Orme, JF Jr. & Morris, AH The changing face of organ failure in ARDS. Chest 1241871–1879 (2003).
Dowell, JC, Parvathaneni, K., Thomas, NJ, Khemani, RG & Yehya, N. Epidemiology of cause of death in pediatric acute respiratory distress syndrome. Crit. Med Care 461811 (2018).
Kallet, RH, Lipnick, MS, Zhuo, H., Pangilinan, LP, and Gomez, A. Features of non-pulmonary organ dysfunction in early ARDS according to the Berlin definition. Breathe. Care https://doi.org/10.4187/respcare.06165 (2019).
Del Sorbo, L. & Slutsky, AS Acute respiratory distress syndrome and multiple organ failure. Running. Notice. Crit. Care 171–6 (2011).
Khemani, RG et al. Incidence and epidemiology of pediatric acute respiratory distress syndrome (PARDIE): An international observational study. Lancet Breathe. Med. seven115-128 (2019).
Weiss, SL et al. Multivisceral dysfunction in mechanically ventilated children for acute respiratory failure. Pediatrician Crit. Med Care 18319 (2017).
Lopez-Fernandez, Y. et al. Pediatric acute lung injury epidemiology and natural history study: incidence and course of acute respiratory distress syndrome in children. Crit. Med Care 403238–3245 (2012).
PALICC Group, Flori, H., Dahmer, MK, Sapru, A. & Quasney, MW Comorbidities and Severity Assessment of Pediatric Acute Respiratory Distress Syndrome: Proceedings of the Pediatric Acute Lung Injury Consensus Conference. Pediatrician Crit. Med Care 16S41–S50 (2015).
Dorinsky, PM & Gadek, JE Mechanisms of non-pulmonary multi-organ failure in ARDS. Chest 96885–892 (1989).
Morgan, T. The oxyhemoglobin dissociation curve in critical illness. Crit. Resusc. 193 (1999).
Morgan, T. The importance of P50. In Yearbook of Critical Care and Emergency Medicine 1999 (ed. Vincent, JL) 433–447 (Springer, 1999).
PALICC group. Pediatric acute respiratory distress syndrome: consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatrician Crit. Med Care 16428 (2015).
Doyle, DJ A simple method for calculating P50 from a single blood sample. Int. J. Clin. Monit. Calculation. 14109–111 (1997).
Hill, AV The possible effects of hemoglobin molecule aggregation on its dissociation curves. J. Physiol. 404–7 (1910).
Wimberly, P. et al. Guidelines for the routine measurement of the oxygen affinity of blood hemoglobin: International Federation for Clinical Chemistry (IFCC). Scan. J. Clin. Laboratory. Invest. 50227–234 (1990).
Zipursky, A., Neelands, PJ, Pollock, J., Chown, B. & Israels, LG The distribution of fetal hemoglobin in the blood of normal children and adults. Pediatrics 30262-268 (1962).
Pediatrics GFdRedU et al. PELOD-2: An Updated Pediatric Logistic Organ Dysfunction Score. Crit. Med Care 411761-1773 (2013).
Pediatrics GFdRedU et al. The pediatric non-respiratory logistic organ dysfunction score-2 is a good predictor of mortality in children with acute respiratory failure. Pediatrician Crit. Med Care 15590-593 (2014).
Lange, T., Vansteelandt, S. & Bekaert, M. A simple unified approach to estimate natural direct and indirect effects. A m. J. Epidemiol. 176190-195 (2012).
Khadaroo, RG & Marshall, JC ARDS and Multiple Organ Dysfunction Syndrome: Common Mechanisms of a Common Systemic Process. Crit. Clin. 18127–141 (2002).
Bhatia, M. & Moochhala, S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J. Pathol. 202145-156 (2004).
Crimi, E. & Slutsky, AS Inflammation and acute respiratory distress syndrome. Best practice. Res. Clin. Anesthesia. 18477–492 (2004).
Spadaro, S. et al. Biomarkers of acute respiratory distress syndrome and prospects for personalized medicine. J. Inflamm. 161 (2019).
Marshall, JC Inflammation, coagulopathy and pathogenesis of multiple organ dysfunction syndrome. Crit. Med Care 29S99–S106 (2001).
Meduri, GU, Annane, D., Chrousos, GP, Marik, PE & Sinclair, SE Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy. Chest 1361631-1643 (2009).
Watson, RS, Crow, SS, Hartman, ME, Lacroix, J. & Odetola, FO Epidemiology and outcomes of pediatric multiple organ dysfunction syndrome (MODS). Pediatrician Crit. Med Care 18S4 (2017).
Proulx, F., Gauthier, M., Nadeau, D., Lacroix, J. & Farrell, CA Timing and predictors of death in pediatric patients with multiple organ failure. Crit. Med Care 221025-1031 (1994).
Flori, HR, Glidden, DV, Rutherford, GW & Matthay, MA Pediatric acute lung injury: prospective assessment of risk factors associated with mortality. A m. J. Breathe. Crit. Med Care 171995–1001 (2005).
Yehya, N., Servaes, S. & Thomas, NJ Characterization of degree of lung injury in pediatric acute respiratory distress syndrome. Crit. Med Care 43937–946 (2015).
Srinivasan, AJ, Morkane, C., Martin, DS & Welsby, IJ Should p50 modulation be a therapeutic target in critically ill people?. Expert Rev. Hematol. ten449–458 (2017).
Morgan, TJ What is p50 (2003).
Myburgh, J., Webb, R. & Worthley, L. P50 is reduced in critically ill patients. Intensive Care Med. 17355–358 (1991).
McLellan, SA & Walsh, TS Concentration of red blood cells 2,3-diphosphoglycerate and P50 in vivo at onset of severe disease. Crit. Med Care 332247-2252 (2005).
Morgan, T., Koch, D., Morris, D., Clague, A., and Purdie, D. Reduction in 2,3-diphosphoglycerate concentrations in severe disease without a decrease in P50 in vivo. Anesthesia. Intensive care 29479–483 (2001).
Huang, W., Cade, J. & Pain, M. Oxygen dissociation curve in adult respiratory distress syndrome. Anesthesia. Intensive care 20456–459 (1992).
Clerbaux, T., Detry, B., Reynaert, M. & Frans, A. Right shift of the oxyhemoglobin dissociation curve in acute respiratory distress syndrome. Periodontol. Biol. 45269-273 (1997).
Severinghaus, JW Blood Gas Calculator. J.Appl. Physiol. 211108-1116 (1966).